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Livres
Articles (41)
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Epigenome-wide association studies for common human diseases

Rakyan, Vardhman K., Down, Thomas A., Balding, David J., Beck, Stephan

Journal:

Nature Reviews Genetics

Année:

2011

Langue:

english

Fichier:

PDF, 440 KB

english, 2011

A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis

Down, Thomas A, Rakyan, Vardhman K, Turner, Daniel J, Flicek, Paul, Li, Heng, Kulesha, Eugene, Gräf, Stefan, Johnson, Nathan, Herrero, Javier, Tomazou, Eleni M

Journal:

Nature Biotechnology

Année:

2008

Langue:

english

Fichier:

PDF, 984 KB

english, 2008

Metastable epialleles in mammals

Vardhman K Rakyan, Marnie E Blewitt, Riki Druker, Jost I Preis, Emma Whitelaw

Journal:

Trends in Genetics

Année:

2002

Langue:

english

Fichier:

PDF, 47 KB

english, 2002

Transgenerational inheritance of non-genetically determined phenotypes

Holland, Michelle L., Rakyan, Vardhman K.

Journal:

Biochemical Society Transactions

Année:

2013

Langue:

english

Fichier:

PDF, 423 KB

english, 2013

Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus

Bell, Christopher G., Finer, Sarah, Lindgren, Cecilia M., Wilson, Gareth A., Rakyan, Vardhman K., Teschendorff, Andrew E., Akan, Pelin, Stupka, Elia, Down, Thomas A., Prokopenko, Inga, Morison, Ian M.

Journal:

PLoS ONE

Année:

2010

Langue:

english

Fichier:

PDF, 361 KB

english, 2010

The hunt for the epiallele

Sarah Finer, Michelle L. Holland, Lisa Nanty, Vardhman K. Rakyan

Journal:

Environmental and Molecular Mutagenesis

Année:

2011

Langue:

english

Fichier:

PDF, 397 KB

english, 2011

Generation of a genomic tiling array of the human Major Histocompatibility Complex (MHC) and its application for DNA methylation analysis

Eleni M Tomazou, Vardhman K Rakyan, Gregory Lefebvre, Robert Andrews, Peter Ellis, David K Jackson, Cordelia Langford, Matthew D Francis, Liselotte Bäckdahl, Marcos Miretti, Penny Coggill, Diego Ottav

Journal:

BMC Medical Genomics

Année:

2008

Langue:

english

Fichier:

PDF, 4.68 MB

english, 2008

Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus

Christopher G Bell, Andrew E Teschendorff, Vardhman K Rakyan, Alexander P Maxwell, Stephan Beck, David A Savage

Journal:

BMC Medical Genomics

Année:

2010

Langue:

english

Fichier:

PDF, 1.14 MB

english, 2010

Extracellular ATP couples to cAMP generation and granulocytic differentiation in human NB4 promyelocytic leukaemia cells

Van Der Weyden, Louise, Rakyan, Vardhman, Luttrell, Brian M, Morris, Michael B, Conigrave, Arthur D

Journal:

Immunology & Cell Biology

Année:

2000

Langue:

english

Fichier:

PDF, 344 KB

english, 2000

DNA methylation profiling of human chromosomes 6, 20 and 22

Eckhardt, Florian, Lewin, Joern, Cortese, Rene, Rakyan, Vardhman K, Attwood, John, Burger, Matthias, Burton, John, Cox, Tony V, Davies, Rob, Down, Thomas A

Journal:

Nature Genetics

Année:

2006

Langue:

english

Fichier:

PDF, 362 KB

english, 2006

The methylome: approaches for global DNA methylation profiling

Stephan Beck, Vardhman K. Rakyan

Journal:

Trends in Genetics

Année:

2008

Langue:

english

Fichier:

PDF, 303 KB

english, 2008

Transgenerational epigenetic inheritance

Vardhman Rakyan, Emma Whitelaw

Journal:

Current Biology

Année:

2003

Langue:

english

Fichier:

PDF, 59 KB

english, 2003

Protection against De Novo Methylation Is Instrumental in Maintaining Parent-of-Origin Methylation Inherited from the Gametes

Proudhon, Charlotte, Duffié, Rachel, Ajjan, Sophie, Cowley, Michael, Iranzo, Julian, Carbajosa, Guillermo, Saadeh, Heba, Holland, Michelle L., Oakey, Rebecca J., Rakyan, Vardhman K., Schulz, Reiner, B

Journal:

Molecular Cell

Année:

2012

Langue:

english

Fichier:

PDF, 1.25 MB

english, 2012

Epigenetic variation and inheritance in mammals

Vardhman K Rakyan, Stephan Beck

Journal:

Current Opinion in Genetics & Development

Année:

2006

Langue:

english

Fichier:

PDF, 170 KB

english, 2006

Sites of Differential DNA Methylation between Placenta and Peripheral Blood: Molecular Markers for Noninvasive Prenatal Diagnosis of Aneuploidies

Elisavet A. Papageorgiou, Heike Fiegler, Vardhman Rakyan, Stephan Beck, Maj Hulten, Klea Lamnissou, Nigel P. Carter, Philippos C. Patsalis

Journal:

The American Journal of Pathology

Année:

2009

Langue:

english

Fichier:

PDF, 224 KB

english, 2009

The hunt for mammalian epialleles

Vardhman Rakyan

Journal:

BMC Proceedings

Année:

2012

Langue:

english

Fichier:

PDF, 67 KB

english, 2012

Marmal-aid – a database for Infinium HumanMethylation450

Lowe, Robert, Rakyan, Vardhman K

Journal:

BMC Bioinformatics

Année:

2013

Langue:

english

Fichier:

PDF, 453 KB

english, 2013

Dipyrone misuse

Gemma, Carolina, Ramagopalan, Sreeram V, Down, Thomas A, Beyan, Huriya, Hawa, Mohammed I, Holland, Michelle L, Hurd, Paul J, Giovannoni, Gavin, David Leslie, R, Ebers, George C, Rakyan, Vardhman K

Journal:

Reactions Weekly

Année:

2013

Langue:

english

Fichier:

PDF, 128 KB

english, 2013

Amoxicillin/clavulanic acid

Gemma, Carolina, Ramagopalan, Sreeram V, Down, Thomas A, Beyan, Huriya, Hawa, Mohammed I, Holland, Michelle L, Hurd, Paul J, Giovannoni, Gavin, David Leslie, R, Ebers, George C, Rakyan, Vardhman K

Journal:

Reactions Weekly

Année:

2013

Langue:

english

Fichier:

PDF, 127 KB

english, 2013

Batch traceability of unsafe biodrugs needs to improve

Gemma, Carolina, Ramagopalan, Sreeram V, Down, Thomas A, Beyan, Huriya, Hawa, Mohammed I, Holland, Michelle L, Hurd, Paul J, Giovannoni, Gavin, David Leslie, R, Ebers, George C, Rakyan, Vardhman K

Journal:

Reactions Weekly

Année:

2013

Langue:

english

Fichier:

PDF, 111 KB

english, 2013

Daptomycin/linezolid/tigecycline

Gemma, Carolina, Ramagopalan, Sreeram V, Down, Thomas A, Beyan, Huriya, Hawa, Mohammed I, Holland, Michelle L, Hurd, Paul J, Giovannoni, Gavin, David Leslie, R, Ebers, George C, Rakyan, Vardhman K

Journal:

Reactions Weekly

Année:

2013

Langue:

english

Fichier:

PDF, 128 KB

english, 2013

Inactive or moderately active human promoters are enriched for inter-individual epialleles

Gemma, Carolina, Ramagopalan, Sreeram V, Down, Thomas A, Beyan, Huriya, Hawa, Mohammed I, Holland, Michelle L, Hurd, Paul J, Giovannoni, Gavin, David Leslie, R, Ebers, George C, Rakyan, Vardhman K

Journal:

Genome Biology

Année:

2013

Langue:

english

Fichier:

PDF, 743 KB

english, 2013

1032 Host-Environment Interactions Shape the Risk for Ulcerative Colitis: Results From a Twin Epigenome-Wide Association Study

Haesler, Robert, Feng, Zhe, Bäckdahl, Liselotte, Spehlmann, Martina E., Franke, Andre, Teschendorff, Andrew, Rakyan, Vardhman, Down, Thomas A., Wilson, Gareth A., Feber, Andrew, Beck, Stephan, Schreib

Journal:

Gastroenterology

Année:

2013

Langue:

english

Fichier:

PDF, 342 KB

english, 2013

Correcting for cell-type composition bias in epigenome-wide association studies

Robert Lowe,Vardhman K Rakyan

Journal:

Genome Medicine

Année:

2014

Langue:

english

Fichier:

PDF, 100 KB

english, 2014

Novel DNA methylation profiles associated with key gene regulation and transcription pathways in blood and placenta of growth-restricted neonates

Hillman, Sara L, Finer, Sarah, Smart, Melissa C, Mathews, Chris, Lowe, Robert, Rakyan, Vardhman K, Hitman, Graham A, Williams, David J

Journal:

Epigenetics

Année:

2015

Langue:

english

Fichier:

PDF, 1.10 MB

english, 2015

The human blood DNA methylome displays a highly distinctive profile compared with other somatic tissues

Lowe, Robert, Slodkowicz, Greg, Goldman, Nick, Rakyan, Vardhman K

Journal:

Epigenetics

Année:

2015

Langue:

english

Fichier:

PDF, 2.35 MB

english, 2015

The promise and challenges of blood spot methylomics

Ramagopalan, Sreeram V, Rakyan, Vardhman K

Journal:

Epigenetics

Année:

2013

Langue:

english

Fichier:

PDF, 542 KB

english, 2013

Buccals are likely to be a more informative surrogate tissue than blood for epigenome-wide association studies

Lowe, Robert, Gemma, Carolina, Beyan, Huriya, Hawa, Mohammed I., Bazeos, Alexandra, Leslie, R. David, Montpetit, Alexandre, Rakyan, Vardhman K., Ramagopalan, Sreeram V.

Journal:

Epigenetics

Année:

2013

Langue:

english

Fichier:

PDF, 3.08 MB

english, 2013

Identification of Type 1 Diabetes–Associated DNA Methylation Variable Positions That Precede Disease Diagnosis

Rakyan, Vardhman K., Beyan, Huriya, Down, Thomas A., Hawa, Mohammed I., Maslau, Siarhei, Aden, Deeqo, Daunay, Antoine, Busato, Florence, Mein, Charles A., Manfras, Burkhard, Dias, Kerith-Rae M., Bell,

Journal:

PLoS Genetics

Année:

2011

Langue:

english

Fichier:

PDF, 293 KB

english, 2011

Sexually dimorphic gene expression emerges with embryonic genome activation and is dynamic throughout development

Lowe, Robert, Gemma, Carolina, Rakyan, Vardhman K, Holland, Michelle L

Journal:

BMC Genomics

Année:

2015

Langue:

english

Fichier:

PDF, 1.24 MB

english, 2015

Extracellular ATP couples to cAMP generation and granulocytic differentiation in human NB4 promyelocytic leukaemia cells

WEYDEN, LOUISE VAN DER, RAKYAN, VARDHMAN, LUTTRELL, BRIAN M, MORRIS, MICHAEL B, CONIGRAVE, ARTHUR D

Journal:

Immunology & Cell Biology

Année:

2000

Langue:

english

Fichier:

PDF, 336 KB

english, 2000

Integrated analysis of genome-wide genetic and epigenetic association data for identification of disease mechanisms

Ke, Xiayi, Cortina-Borja, Mario, Silva, Bruno Cesar, Lowe, Robert, Rakyan, Vardhman, Balding, David

Journal:

Epigenetics

Année:

2013

Langue:

english

Fichier:

PDF, 1.74 MB

english, 2013

The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans

Lowe, Robert, Overhoff, Marita G., Ramagopalan, Sreeram V., Garbe, James C., Koh, James, Stampfer, Martha R., Beach, David H., Rakyan, Vardhman K., Bishop, Cleo L.

Journal:

Genome Biology

Année:

2015

Langue:

english

Fichier:

PDF, 2.56 MB

english, 2015

The marks, mechanisms and memory of epigenetic states in mammals

RAKYAN, Vardhman K., PREIS, Jost, MORGAN, Hugh D., WHITELAW, Emma

Journal:

Biochemical Journal

Année:

2001

Langue:

english

Fichier:

PDF, 207 KB

english, 2001

The marks, mechanisms and memory of epigenetic states in mammals

RAKYAN, Vardhman K., PREIS, Jost, MORGAN, Hugh D., WHITELAW, Emma

Journal:

Biochemical Journal

Année:

2001

Langue:

english

Fichier:

PDF, 207 KB

english, 2001

Correlation of an epigenetic mitotic clock with cancer risk

Yang, Zhen, Wong, Andrew, Kuh, Diana, Paul, Dirk S., Rakyan, Vardhman K., Leslie, R. David, Zheng, Shijie C., Widschwendter, Martin, Beck, Stephan, Teschendorff, Andrew E.

Journal:

Genome Biology

Année:

2016

Langue:

english

Fichier:

PDF, 3.06 MB

english, 2016

eFORGE: A Tool for Identifying Cell Type-Specific Signal in Epigenomic Data

Breeze, Charles E., Paul, Dirk S., van Dongen, Jenny, Butcher, Lee M., Ambrose, John C., Barrett, James E., Lowe, Robert, Rakyan, Vardhman K., Iotchkova, Valentina, Frontini, Mattia, Downes, Kate, Ouw

Journal:

Cell Reports

Année:

2016

Langue:

english

Fichier:

PDF, 4.75 MB

english, 2016

DNA methylation profiles between airway epithelium and proxy tissues in children

Brugha, Rossa, Lowe, Robert, John Henderson, A., Holloway, John W., Rakyan, Vardhman, Wozniak, Eva, Mahmud, Nadiya, Seymour, Kay, Grigg, Jonathan, Shaheen, Seif O.

Journal:

Acta Paediatrica

Année:

2017

Langue:

english

Fichier:

PDF, 285 KB

english, 2017

Early life diet conditions the molecular response to post-weaning protein restriction in the mouse

Danson, Amy F., Marzi, Sarah J., Lowe, Robert, Holland, Michelle L., Rakyan, Vardhman K.

Journal:

BMC Biology

Année:

2018

Langue:

english

Fichier:

PDF, 1.62 MB

english, 2018

BulkVis: a graphical viewer for Oxford nanopore bulk FAST5 files

Payne, Alexander, Holmes, Nadine, Rakyan, Vardhman, Loose, Matthew, Birol, Inanc

Journal:

Bioinformatics

Année:

2018

Langue:

english

Fichier:

PDF, 1.42 MB

english, 2018

The DNA methylome of human sperm is distinct from blood with little evidence for tissue-consistent obesity associations

Ãsenius, Fredrika, Gorrie-Stone, Tyler J., Brew, Ama, Panchbhaya, Yasmin, Williamson, Elizabeth, Schalkwyk, Leonard C., Rakyan, Vardhman K., Holland, Michelle L., Marzi, Sarah J., Williams, David J.,

Journal:

PLoS Genetics

Année:

2020

Fichier:

PDF, 3.47 MB

2020